Endocrine Abstracts

Background: Acromegaly is associated with increased risk of coronary atherosclerosis and cardiovascular mortality. Changes in coagulation and fibrinolysis markers in acromegalic patients have been shown to indicate increase in the risk of developing cardiovascular disease. Mean platelet volume (MPV) is a marker of platelet functions and activity, and increased MPV is an independent risk factor of myocardial infarction and thrombotic events. In this study, we examined the level...

Introduction: Differentiated thyroid carcinoma (DTC) rarely represents with distant organ metastasis. Cerebral metastasis is seen in 0.4–1.2% of patients with distant organ metastasis. There are only 14 patients of DTC with pituitary metastasis reported in the literature. Here, we report a papillary thyroid carcinoma (PTC) patient represented with pituitary metastasis.Case: A 68-year-old male patient has admitted to our hospital with a growing tumou...

Introduction: ‘Atypia of undetermined significance/follicular lesion of undetermined significance’ (AUS/FLUS) is a heterogeneous diagnostic thyroid fine needle aspiration biopsy (FNAB) category. AUS/FLUS is comprised of cases that cannot be definitively diagnosed as benign, suspicious for/consistent with neoplasm, suspicious for malignancy or malignant. The recommended management strategy for these cases is to perform a repeat FNAB after an appropriate time course. A...

Background: Insulinoma is a rare tumour representing 1–2% of all pancreatic neoplasms and it is malignant in only 10% of cases. Locoregional invasion or metastases define malignancy, whereas dimension (> 2 cm), CK19 status, tumor staging and grading (Ki67 > 2%), and age of onset (> 50 years) can be considered elements of suspect.Case presentation: We report a case of malignant insulinoma in a 80 year old woman presenting symptoms c...

Aim: Subclinical Hypothyroidism (SH) is associated with cardiovascular disorders which may include increased risk for atherosclerosis, endothelial dysfunction and myocardial dysfunction.To investigate the prevalence of left ventricular systolic and diastolic dysfunction in patients with subclinical hypothyroidism and the effect of L-thyroxin therapy on myocardial performance using conventional echocardiographic parameters.Method: The study includes 95 pa...

Objective: Insulin insufficiency which is the result of deficiency of β-cells is the common feature for all types of diabetes. Therefore protection of functional β-cell mass is the keystone of diabetes treatment. Betatrophin, a newly determined hormone, has been identified as a potent stimulator that increases the production and expansion of β-cells in mice. However, very little is known about the physiological role of betatrophin in h...

Type III PAS is defined as autoimmune thyroiditis occurs with another organ-specific autoimmune disease. Further PAS IIIA is subclassified as autoimmune thyroiditis with immune-mediated diabetes mellitus. Circulating organ-specific autoantibodies can be detected in these patients. We report a patient with Hashimoto Thyroiditis since five years on levothyroxine treatment with normal TSH levels and new onset insulin dependent Type I DM for 3 months. The patient was admitted Recu...

Introduction: Langerhans cell histiocytosis (LCH) is a multisystem neoplastic disease with primarily bone and skin involvement. Although its pathogenesis is still not fully understood, LCH lesions contain clonal CD 207+ dendritic cells with the frequently identified BRAF V600E mutation and an inflammatory component. Although isolated central nervous system involvement is extremely rare, a common site of involvement is the hypothalamic-pituitary axis.Case...

Introduction: Insulinoma is the most common functional pancreatic neuroendocrine tumor (PanNET), accounting for more than 50% of all cases. Diagnosis of insulinomas may be challenging. In this study, we aim to discuss the clinicopathological features and long-term follow-up results of insulinoma cases followed up in our clinic.Material and Methods: It is a descriptive and retrospective study of 13 insulinoma cases diagnosed over 10 years. All data of the...

Introduction: Thyroid papillary cancer is a solid organ malignancy that can be cured mostly by surgical and radioactive iodine(RAI) therapy. Metastatic disease state and radioactive iodine resistance have led to new treatment searches. In recent years, sorafenib, a tyrosine kinase inhibitor, has been used as a first-line treatment in thyroid papillary cancers that cannot be cured by surgery or radioactive iodine treatment. In addition, the use of thermal ablation and transarte...